cytoskeleton bad at its job??
As we know, the cytoskeleton provides cell shape and movement of the cell, along with all of its organelles. The cytoskeleton causes many cardiovascular diseases, neurodegeneration, cancer, cirrhosis, and even skin diseases! Some include:
We depend on the cytoskeleton to keep us in place so we can efficiently do our jobs, and if we can’t trust it with a simple job like staying in place, how will we be able to trust it in with all the power?
- Wiskott –Aldrich Syndrome- Characterized by immune dysregulation, microthrombocytopenia, eczema, and lymphoid malignancies. The lack of the WAS protein results in cytoskeleton defects that causes the normal functions of the organelle to malfunction, including phagocytosis, immune synapse formation, adhesion and directed migration.
- Sickle Cell Anemia- Causes red blood cells to become abnormally shaped due to the cytoskeleton not keeping the proteins actin and spectrin in place, subjecting the red blood cell to a malleable structure. The cell becomes deformed and fragile, causing a shortening of red blood cells. This disease is characterized by swollen hands and feet, spleen damage, delayed growth in youth, and vison problems.
We depend on the cytoskeleton to keep us in place so we can efficiently do our jobs, and if we can’t trust it with a simple job like staying in place, how will we be able to trust it in with all the power?